SEPARATION, ANALYSIS, AND CONDUCTIVITY MEASUREMENTS OF ACTIVE PHARMACEUTICAL INGREDIENT (API) OF NAPROXEN

Abstract

The drug used was Naproxen is NSAID from propionic acid class used to treat pain. This study was aimed to determine a suitable separation method for active pharmaceutical ingredient from tablet solid dosage form, maintaining the environment through separation of an API from expired drug, discover the effect of sunlight on API, determine the pH of active ingredient and put it in curve and to measure the EC and PPM of the drug. In the experiment a mortar and pestle were used to crush 5 tablets of Naproxen then used 50ml of ether and 50ml of distilled water (1:1) as solvent, stirrer to enhance solubility and separatory funnel for extraction process then dried at room temperature 25Ċ for four days. melting point apparatus was used to confirm identification of the pure sample of Naproxen and acid base titration to determine the acidity concentration of it .The EC,PPM and pH was measured by(Adwa PH meter , AD31 Waterproof Conductivity-TDS-TEMP Pocket Testers) ,the measurement started after taken 100mg of Naproxen powder crystal dissolved in 50ml ethanol and 50ml of distilled water followed by addition of known volume of NaOH 4ml the measurement was repeated eight times with addition of 4ml of NaOH and 100mg of Naproxen powder each time of measurement, then the last measurement was done after exposure under UV lamp by using 100mg of Naproxen powder dissolved in 50ml ethanol and 50ml of distilled water and with addition of 4ml of NaOH .The results presented showed a formed crystal of pure Naproxen after Four days , for purity identification melting point apparatus was used , sample start to melt at 152Ċ as listed, noticeable increase in EC,PPM and pH values ,proportionally related with the weight because of interaction between acidic group in Naproxen (COOH) with NaOH, relationship between weight and Concentration was determined curve plotted shown increase in concentration each time the weight increase which result increase in electrical conductivity of the drug ,then pH was determined and curve plotted through acid base titration. In the last measurement viewed Change in drug Solution values EC, TDS and pH after UV exposure for six hours due to breaking of drug salt particles. This method proposed here it was considered to be simple, cheap and acceptable which fulfill the aims needed.