Separation, Analysis, And Conductivity Measurements Of Active Pharmaceutical Ingredient (API) Of Ibuprofen

Abstract

This study was conducted to achieve the following objectives: Determination of an appropriate separation method for the active pharmaceutical universe from tablets of ibuprofen, Preserving the environment by separating the active substance from the expired drug and using it for other purposes. Discover the effect of sunlight on the active substance by exposing it to ultraviolet rays. Determine the pH of the active ingredient, draw the curve, measure the conductivity and the percentage of salts. The drug used to conduct this study was Ibuprofen is derived from propionic acid and is a non-steroidal anti-inflammatory drug used to treat pain, fever, and inflammation. This includes menstrual pain, migraines, and rheumatoid arthritis. It can be used to block an open ductus arteriosus in premature babies. It is taken orally or intravenously, and it will take effect within an hour. A mortar and pestle was used to crush (10) tablet of ibuprofen then used 50ml of ether and 50ml of distilled water ( 1:1 ) as solvent, stirrer to enhance solubility and separatory funnel for extraction process then dried at room temperature 25Ċ for five couple of days. melting point apparatus used to confirm identification of the pure sample of ibuprofen and acid base titration to determine the acidity concentration of it .The EC,PPM and pH measured by(Adwa PH meter , AD31 Waterproof Conductivity-TDS-TEMP Pocket Testers) measurement started after taken 100mg of ibuprofen powder crystal dissolved in 50ml ethanol and 50ml of distilled water followed by addition of known volume of NaOH 4.8ml (to know the exact volume needed see page no. ) repeated eight times with addition of 4.8ml of NaOH and 100mg of ibuprofen powder each time of measurement, the next measurement done after exposure under UV lamp by using 100mg of ibuprofen powder dissolved in 50ml ethanol and 50ml of distilled water and addition of 4ml of NaOH .The results presented showed a formed crystal of pure ibuprofen after five days , for purity identification melting point apparatus was used , sample start to melt at 77Ċ as listed, noticeable increase in EC,PPM and pH values ,proportionally related with the weight because of interaction between acidic group in ibuprofen (COOH) with NaOH, law and curve was used to determine the relationship between weight and Concentration ,pH was marked and curve plotted through acid base titration. Chang in drug Solution values EC, PPM and pH after UV exposure for six hours due breaking of drug salt particles. This method proposed here was simple, cheap and acceptable which fulfil the aims needed.