SEPARATION, ANALYSIS, AND CONDUCTIVITY MEASUREMENTS OF ACTIVE PHARMACEUTICAL INGREDIENT (API) OF KETOPROFEN

Abstract

The compound Ketoprofen, which is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID). The aims of the following study are to determine an appropriate method for separation of the API Ketoprofen (ketofan) from its original drug, to measuring the conductivies of different concentration of the API, studying the effect of UV wave on the API, drawing its Ph. curve. The active substance was separated by extraction, where it was discovered that the active substance dissolves in ether, not dissolved in water, and from this experiment an appropriate amount of the pure active substance was obtained. The conductivity and the percentage of dissolved salts of the compound were measured using a conductive probe. The obtained values were monitored in a curve showing the relationship between the different Ketoprofen concentrations and the conductivity. Thus, electrical conductivity can be used as a measure of concentration. The change in conductivity values was concluded after the compound was exposed to ultraviolet rays, where the significant effect of sunlight on the active substance was confirmed. To identify the PH curve of the active substance was used acid base Titration.