Antimicrobial Susceptibility of Staphylococcus aureus isolated from Clinical Isolates of Patients in El Jalaa Hospital for Surgery and Accidents in Benghazi City – Libya

Abstract

Background: Staphylococcus aureus cause disease through the production of toxin or through direct invasion and destruction of tissue. Staphylococci have a record of developing resistance quickly and successfully to antibiotics. Objectives: To evaluate antibiotic resistance trends in Staphylococcus aureus over time. Materials and Methods: One hundred and ten consecutive isolates of S. aureus obtained from various clinical specimens between January 2022 to April 2022 sent to the Medical Microbiology Laboratory Department of El Jalaa Hospital for Surgery and Accidents in Benghazi City – Libya, and the standard procedures for bacteriology were applied to the isolates. Antibiotic sensitivity pattern was carried out by disc diffusion method. Results: In this study, among 14 (12.7%) samples from males and 96 (87.3%) samples from women suspected of having gram-positive bacteria. Most of Staphylococcus aureus isolate was from age group between (30-45 years) 36.4%. Urine isolates 97(88.2%), the highest specimen S. aureus isolates followed by swab 11(10%). The most common drug sensitivity in the S. aureus isolates were to sensitivity to gentamicin and ciprofloxacin 73 (66.4%) while the most common drug resistance was to sulfamethoxazole 54 (49.1%) and azithromycin 75 (68.2). In our study found a strong significant relationship between sex and Doxycycline antibiotic, where (p. value=0.002) and between age and Augmentin antibiotic, where (p. value = 0.038). this study was recorded a significant relationship between (age & sex) & (sex and samples) where (p. value=0.05). Conclusions: It is known that the degree of resistance or sensitivity of Staphylococcus aureus to the antibiotics used varies from one region to another, so this study is useful in guiding the experimental treatment caused by Staphylococcus aureus and helps epidemiologists understand the nature of isolates of this bacteria in this part of Libya.