In Vitro Study of Fusidic Acid Susceptibility amongst Isolates from Various Swabs
Keywords:
impetigo, antibiotic resistance, dermatological infections, infectionsAbstract
Fusidic acid is a common therapy for staphylococcal infections in Libya. The most common causes of superficial pyoderma are Staphylococcus aureus (77%) and Streptococcus pneumonia (2.2%), but reports have suggested high rates of resistance among clinical isolates. Susceptibility testing of S. aureus to fusidic acid is further complicated by the lack of consensus on mean inhibitory concentrations (MIC) and disk diffusion cutoffs to determine resistance. The purpose of this study was to determine the correlation between disk diffusion and Etest determined MIC susceptibility results in clinical isolates of S. aureus from Al-salem Medical laboratory. The swab infection rate was higher in males than in females. The most bacteria found were S. aureus, 57 isolates (77%) and Strep pneumoniae 9 isolates (12.2%). Almost isolated strains showed a high ratio of intermediate to fusidic acid. The susceptibility test for fusidic acid, found that 4% of Staph aureus isolates and Strep pneumonia isolates (1%) were susceptible to fusidic acid. The results of this study showed that there has been in vitro low susceptible of Gram positive cocci to fusidic acid. Therefore, fusidic acid is not recommended for use as Empirical treatment
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